Understanding the prevalence and dissemination aminoglycoside resistance genes

Selecting the suitable antibiotics to deal with bacterial infections has grown tougher due to the emergence of antibiotic-resistant micro organism. Aminoglycosides, as broad-spectrum antibiotics, are more and more getting used clinically; nevertheless, for handiest employment of aminoglycosides, a complete understanding of aminoglycoside resistance genes’ prevalence and dissemination is required.

Due to this fact, to higher perceive the worldwide resistance standing of aminoglycoside antibiotics and the prevalence of antibiotic-resistance genes (ARGs) in varied bacterial species, this text gathers related information from a number of research. Two major resistance mechanisms—aminoglycoside enzymatic modification and 16S rRNA methylation—had been assessed, and the prevalence of the corresponding ARGs was described.

The coexistence of aminoglycoside ARGs with different ARGs was additionally demonstrated, as was the connection between aminoglycoside ARGs and resistant phenotypes. The dearth of efficient therapeutic brokers to fight resistant pathogens presents an actual menace to public well being. The mix of aminoglycosides with different antibiotics could present a novel therapy technique.

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Journal reference:

Zhang, Y., et al. (2023). The prevalence and distribution of aminoglycoside resistance genes. Biosafety and Well being. doi.org/10.1016/j.bsheal.2023.01.001