Examine determines the diagnostic utility of liver stiffness measurement

Even after continual hepatitis C has been cured, portal hypertension stays the foremost issue driving the event of problems in superior liver illness. In cooperation with researchers from Spain, a analysis workforce led by Georg Semmler and Mattias Mandorfer from the Division of Gastroenterology and Hepatology at MedUni Vienna’s Division of Drugs III confirmed that the non-invasive exams explored of their earlier research precisely estimate the likelihood of sequelae. Their examine, printed within the prestigious Journal of Hepatology, refutes considerations in regards to the accuracy of those exams and recommends actions for particular person illness follow-up.

Of their newest examine, the analysis group analysed all printed information referring to non-invasive exams and minimally invasive hepatic venous strain gradient measurements carried out on sufferers earlier than and after remedy for hepatitis C. Working carefully with colleagues from Spain, they evaluated paired measurements from 418 sufferers, confirming the accuracy of two non-invasive exams: US-based liver stiffness measurement and platelet rely, a easy blood check. Based mostly on these findings, it was potential to develop a threat stratification system for sufferers put up hepatitis C treatment and this has already been carried out within the Baveno VII consensus, i.e. the worldwide suggestions for the administration of portal hypertension.

The outcomes of the examine are due to this fact already contributing to the personalised follow-up of those sufferers worldwide, eliminating the necessity for pointless, typically burdensome examinations and enabling early initiation of preventive measures the place acceptable.”

Georg Semmler, Examine First Creator, Medical College of Vienna

Hepatitis C is a viral an infection that’s widespread all through the world. For some years now, it has been efficiently handled with medication which have a direct antiviral impact and may thus be cured in over 95% of instances. Nonetheless, sufferers with superior scarring of the liver (“superior liver illness”) stay susceptible to creating secondary illness. Excluding hepatocellular carcinoma, these problems are instantly attributable to the presence of portal hypertension. This refers to hypertension within the giant vein that transports blood from the intestine to the liver. So as to present follow-up care after hepatitis C, it’s important that portal hypertension might be precisely recognized via non-invasive testing. “Our examine has made it potential to precisely predict particular person threat after hepatitis C has been cured. Whereas it’s potential to stop surveillance in a excessive proportion of sufferers, it’s urgently beneficial that preventive drug remedy is initiated or continued in others,” provides examine chief Matthias Mandorfer.


Medical College of Vienna

Journal reference:

Semmler, G., et al. (2022) Non-invasive exams for clinically important portal hypertension after HCV treatment. Journal of Hepatology. doi.org/ 10.1016/j.jhep.2022.08.025.

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